The Opioid Crisis and HIV

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President Trump recently declared the opioid crisis a public health emergency. Advocates and physician groups say this is a first step in increasing awareness about the opioid crisis and looking at the causes of the epidemic directly, but significantly more needs to be done. The opioid crisis has impacted cities and communities across the nation, including people living with or at risk for HIV. The intersection between opioids and HIV is apparent because HIV can spread through shared needles. For example, Scott County in Indiana experienced an HIV outbreak tied to injection of opioid drugs, resulting in 181 new HIV infections from November 2014 through November 2015. Nationally, 6% of new HIV diagnoses are attributed to injection drug use alone. In addition, approximately 30% of deaths among people with AIDS are attributed to injection drug use.

The Infectious Disease Initiative at the O’Neill Institute for National and Global Health Law has expanded to address the opioid crisis and its relationship to HIV and other infectious diseases such as hepatitis C. Earlier this year, Jeffrey Crowley, Program Director of the Infectious Disease Initiative, co-authored a journal article, “Preventing HIV and Hepatitis Infections Among People Who Inject Drugs: Leveraging an Indiana Outbreak Response to Break the Impasse.” More recently, on October 23, 2017, Jeffrey Crowley participated in a congressional briefing entitled “HIV/AIDS, Viral Hepatitis and Opioids: Using Data and Mapping Technology to Understand Overlapping Epidemics at the National, State and Local Level.” Next month, as part of an event organized by amfAR on December 4, 2017, Jeffrey Crowley will participate in a roundtable discussion on using data to inform the opioid epidemic response.

Another area that we are exploring at the O’Neill Institute is the link between opioid use and HIV criminalization. HIV criminalization describes the unjust application of criminal laws to people living with HIV based solely on their HIV status. Many HIV criminal laws specifically target people living with HIV who inject drugs. Twelve states and one U.S. territory have provisions specifically criminalizing syringe sharing or sale by a person living with HIV. These laws intensify HIV stigma, and as a result, people who inject drugs may be less likely to seek testing or treatment for HIV. Thirty-two states also criminalize the possession of drug paraphernalia, including syringes. Advocates say these laws prevent people from carrying new syringes, which may cause them to share injection equipment and increase the chance that HIV hepatitis C will be spread. These laws run counter to public health best practices and do not reflect the idea that HIV and substance abuse are public health issues.

On November 30, 2017, the O’Neill Institute will host a presentation on HIV Criminalization and the Opioid Crisis in recognition of World AIDS Day. The presentation will include a discussion of HIV criminalization in the United States and its connection to drug and syringe use, before then turning to the opioid crisis and public health efforts in response to the crisis.

This blog post was co-authored by Natalie Dobek, a second-year law student at Georgetown Law and a research assistant at the O’Neill Institute.

Posted in National Healthcare; Tagged: , , , .


Gene Editing: The Health and Ethical Implications

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DNA editing carries profound implications for basic science, medicine, and many other fields.  Gene editing can be used for a variety of different things including research, to treat disease, and for biotechnology.  Gene editing can be used to change the DNA in cells or organisms to understand their biology and how they work.  Genome editing has also been used to modify human blood cells that are then put back into the body to treat conditions including certain types of cancer, such as leukemia.   It can even screen unborn children for diseases before conception.   It has potential for the treatment of infections including MRSA and genetic conditions such as muscular dystrophy and hemophilia.   Additionally, genome editing has been u sed in agriculture to genetically modify crops to improve their yields and for resistance to disease and drought.  It has also been used to genetically modify cattle.

Genome editing uses a type of enzyme called an “engineered nuclease” which cuts the genome in a specific place, thereby altering it.   Afterward, the cell naturally repairs itself.   Scientists are able to manipulate this repair process to make changes—or edits—to the DNA in that location in the genome.   There is also the possibility of removing a section of DNA in order to prevent certain diseases or conditions such as those mentioned above.

The development of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing tool in 2012 has made it possible to precisely engineer cuts and/or edits in DNA at any target sequence, giving researchers unprecedented power and ease to manipulate any genome of their choosing.  Scientists have already reported huge strides using CRISPR to fix disease genes in animal models and human embryos, and clinical trials for blindness, muscular dystrophy, and cancer are imminent.  Scientists have also engineered the pig genome to enable safer organ transplants and are contemplating so-called gene drives to wipe out malaria.

Gene editing can be used to help treat disease but it also raises some important ethical and legal questions related to access, equity, safety, and the specter of human enhancements.  Some of the ethical questions that arise have to do with creating “designer babies.”  Ethicists are debating the power of CRISPR and whether it is right to allow parents to filter out traits they deem undesirable.  Another issue is accessibility.  While such advances in gene editing can be helpful in eradicating genetic disorders and certain diseases, the ability to edit DNA to prevent one’s child from living with chronic conditions such as Huntington’s disease will only be available to an elite class of extremely wealthy people.

However, some people believe that even with CRISPR we will not be living in a world free from genetic diseases.  One of the reasons is that some important diseases are “polygenic,” meaning that more than one gene is responsible for the condition.  And it can often be the case that there are hundreds of genes responsible for any one condition.  One example is the case of autism.  Researchers believe that as many as 1,000 genes may play a role in the development of autism, meaning there is no single gene that can be identified as “the autism gene.”   

Posted in Global Health, Health reform, National Healthcare, Resources; Tagged: , , .


DIALOGUES ON BEING HUMAN: O’Neill Institute Event; Wednesday November 8th on Georgetown University’s Main Campus

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This post was written by Anita Alvin Nilert, Art Dialogues Curator, please direct any questions or comments to an435@georgetown.edu.

DIALOGUES ON BEING HUMAN: The Intersections of Art, Health and Dignity with artist Wangechi Mutu in dialogue Alicia Ely Yamin, Visiting Professor at Georgetown University Law Center and Director of the Health and Human Rights Initiative.

The second in our series, the Art Dialogues seek to make health and human rights issues more visible and comprehensible. By harnessing the power of art to convey the linkages between being human, living with dignity as a subject of rights, and well-being, this series can provide space to explore inter-disciplinary forms of knowing and sharing the human experience. Too often siloed scholarship in and beyond law is limited to forms of knowledge appealing to self-defined, specialized audiences, which can preclude the intuitive reactions that reveal much about the experience of both enjoyment and violation of rights.

Selected artists share evocative artwork that was often created in response to experiences of exclusion or deprivation, or with the aim of expressing what complex human identity means to them. Bringing together these works of art and the artists who create them in one evening of intimate conversation with a leading human rights scholar, invites further reflection and inter-disciplinary dialogues, with the aim of opening people to different dimensions of questions about the meaning of being human and using rights to create social transformation that advances human dignity and well-being.

Participants will experience Wangechi Mutu’s 9 minute film,“The End of Carrying All” where she plays the main character, and later discuss the themes explored in her artwork, including ideas of desire, gender, race, cultural trauma and environmental destruction.

The film follows a woman’s journey across a landscape, carrying a large basket on her head filled to the brim, as many African women still do on a daily basis to feed their families. With every step, the woman’s basket is increasingly filling up with more goods and manufactured objects, including buildings, a bicycle wheel, a satellite dish, a tower, and an oil rig. Eventually, it feels as though the woman is carrying the burdens of all of humanity, our desires and insatiable materialism. She buckles under the weight, eventually disappearing, as this bulge too becomes re-absorbed into the earth. An eruption follows, rumbling under the earth, erasing any trace of the woman and her toil. All is quiet, and as if nothing had ever happened, the whole journey begins again. Mutu says, “My films provide a way for me to enact, represent, what I empathize and value about women. In performing, I’m present, I’m there, alive and captured in time and movement.”

Wangechi recasts female stereotypes, and questions cultural identity and perceptions. Her work touches on the complications of being, and how the physical body plays a significant role in determining experiences, survival, and the ability to understand what that is. Mutu believes, “ Art allows you to imbue the truth with a sort of magic…so it infiltrates the psyches of more people, including those who don’t believe the same things as you”.

Mutu’s collage-paintings, sculpture, installation, film work and performance works are centered on imagery of the female body underscoring how it can act as measuring devices of any society’s well being. She observes, “Females carry the marks, language and nuances of their culture more than the male. Anything that is desired or despised is always placed on the female body”.

Mutu’s work gives viewers an immediate and intimate personal insight into important themes, that words cannot express. She is one of the most widely acclaimed African-born Contemporary artists. Born in Nairobi, Kenya, she lives and works both in New York and Nairobi. Her own diverse history –she has studied both anthropology and sculpture and has also lived in Wales–has given her a unique cross-cultural perspective that informs her work. Wangechi holds an MFA from Yale, and her work has been exhibited in a host of major institutions and museums worldwide.

We are very excited to welcome Wangechi Mutu on November 8th and to collaborate across disciplines with the Art and Art History Department, and co sponsored by the School of Foreign Service and the Office of the Provost.


Wangechi Mutu, stills from The End of carrying All, 2015 –3 Screen Animated Video (color, sound) 9 minutes 27 seconds loop, Edition of 3. Courtesy of the Artist, Gladstone Gallery New York and Brussels, Susanne Vietmetter Los Angeles Projects, and Victoria Miro London.

Posted in Global Health, Human Rights; Tagged: , , , , , , , .


From skilled birth attendants to extreme poverty, truths behind statistics

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Look beneath the statistic, and you might find unexpected realities. Imagine courtesy of Brian Talley.

In an era where established facts are questioned – the massive evidence on climate change and the massive dearth of evidence on voter fraud in the United States, for example – it is worth bearing in mind the following: While believing falsehoods and outright lies and not believing truths can cause great harm, skepticism is indeed warranted when, to help make sense or easily communicate a complex set of facts, we boil those facts down into a single statistic. A line attributed (though not necessarily factually) to Mark Twain captures the point well: “Facts are stubborn things, but statistics are pliable.”

Several recent controversies, findings, and articles remind us of this crucial distinction between reality and the statistics that portend to portray reality:

* Skilled birth attendants and maternal mortality: One question that we should ask about statistics is whether they are the best measure of what they are meant to tell us. A recent article raised questions over the focus on the international community – and in turn, that of many national governments – on the proportion of births attended by skilled birth attendants as the central proxy for maternal mortality, with the policy priorities this entails. Make no mistake: There is  no question that skilled birth attendants are (literally) vitally important. Evidence of their impact on reducing maternal mortality is rife (and see slide 37 of this powerpoint presentation [the link may ask whether you want to open or save the file] on the strong statistical relationship between higher skilled birth attendance and lower maternal mortality, looked at globally).

But while the correlation between the two remains, it is weaker for countries with the highest levels of mortality (see slides 38-39 of the same powerpoint presentation), as the life-saving potential of skilled birth attendants is undermined by the poor functioning health systems of which they are a part. Particularly in these high-mortality settings, might some of the resources being devoted to training skilled birth attendants (midwives, for example) be spent in other ways that would have a greater effect on reducing maternal mortality (leaving aside the availability in the world of resources for both; this ought not be an either/or choice that must be made)? For example, some analysts and development workers argue that because of the hesitancy of midwives to work in rural areas, an even higher priority than training new midwives should be “to assist community health workers, ensure basic antenatal and postnatal care and even improve local transport infrastructure — to ferry emergency cases,” along with training these community health workers to assist with deliveries.

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Recent HIV Updates from the Centers for Disease Control and Prevention

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The Centers for Disease Control and Prevention (CDC) defines the goals of its HIV prevention efforts in the United States to be preventing new HIV infections, improving health outcomes for persons living with HIV, reducing HIV-related disparities and health inequities, and continually improving the effectiveness and efficacy of operations. These goals are reflected in the recently updated Strategic Plan of CDC’s Division of HIV/AIDS Prevention and align with national HIV prevention goals. To make progress in reaching these goals, the Division of HIV/AIDS Prevention works with other federal agencies and state, local, and community partners to ensure that the best prevention and treatment methods are being recommended to people living with or at risk for HIV and their providers. In September, CDC took a huge step in this regard by releasing its “Dear Colleague” announcement in which it stated there was effectively no risk of a person with HIV who has an undetectable viral load transmitting the virus to an HIV-negative partner.

The CDC announcement cited three studies involving thousands of couples and many thousands of acts of sex without a condom or pre-exposure prophylaxis (PrEP), in which there were no cases of HIV transmission from an HIV-positive partner who was virally suppressed to an HIV-negative partner. CDC stated that this means people who take antiretroviral therapy (ART) as prescribed and achieve and maintain an undetectable viral load have effectively no risk of transmitting HIV.

As the announcement was released on National Gay Men’s HIV/AIDS Awareness Day, CDC also included some information on how gay and bisexual men (and other men who have sex with men) are disproportionately affected by HIV. In 2015, more than 26,000 gay and bisexual men received an HIV diagnosis, representing two-thirds of all new diagnosis in the United States. Additionally, among gay and bisexual men living with HIV in 2015, only 61% had achieved viral suppression. This means only 61% had effectively no risk of transmitting HIV.

Following the HIV treatment announcement, CDC released a statement on October 15th in recognition of National Latinx AIDS Awareness Day discussing the impact of HIV/AIDS on Hispanic/Latino persons. In 2015, Hispanics/Latinos accounted for about 25% of all HIV diagnoses in the United States, although they made up only 18% of the total population. Among all Hispanics/Latinos living with HIV in 2014, only 58% had a suppressed viral load. This is particularly concerning given that new HIV infections among Latino gay and bisexual men rose by 20% between 2008 and 2014.

CDC encourages both public and private stakeholders to implement interventions to increase retention in HIV treatment and viral suppression, which would reduce the risk of transmitting HIV to effectively zero. These interventions must focus on disproportionately affected communities, especially gay and bisexual men of color, transgender individuals, and Black women. More must be done in order to reduce racial and ethnic disparities in HIV care outcomes.

This blog post was co-authored by Natalie Dobek, a second-year law student at Georgetown Law and a research assistant at the O’Neill Institute.

Posted in Updates; Tagged: , , .


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